树突状细胞是目前已知的功能最强的抗原递呈细胞 ,可通过表达的Toll样受体 (TLR )来识别病原微生物特有的保守成分 ,如脂多糖、细菌DNA中非甲基化的CpG序列和病毒的dsRNA等 ,并通过TLR介导的信号传导通路激活转录因子NF κB和Jun/Fos,引起炎性细胞因子的释放和促进树突状细胞成熟 ,并且可以影响免疫应答的类型。为制备树突状细胞疫苗提供了一条新思路 Dendritic cells, the most potent antigen-presenting cells known to date, recognize the conserved components of pathogenic microorganisms via expressed Toll-like receptors (TLRs) such as lipopolysaccharides, unmethylated CpG sequence and viral dsRNA, and activate the transcription factors NF-κB and Jun / Fos through TLR-mediated signaling pathways, induce the release of inflammatory cytokines and promote the maturation of dendritic cells, and can influence the type of immune response. It provides a new idea for preparing dendritic cell vaccine