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淋巴因子激活的杀伤细胞(LAK细胞)能广泛杀伤自身肿瘤、同种异体肿瘤。LAK细胞用于恶性肿瘤的过继免疫治疗是近年十分活跃的研究领域。IL—6是一种多功能细胞因子,在机体免疫系统、防御功能及造血调节中有重要作用。已有文献报道,IL—6可诱导IL—2受体表达,提高PHA刺激的细胞毒T细胞(CTL) 的杀瘤活性。本实验观察了IL—6和IL—2合用对人LAK细胞诱导及其杀瘤活性的影响。(1)在诱导LAK细胞克隆的含
Lymphokine-activated killer cells (LAK cells) can widely kill their own tumors, allogeneic tumors. Adoptive immunotherapy of LAK cells for malignant tumors is a very active area of research in recent years. IL-6 is a multifunctional cytokine that plays an important role in the body’s immune system, defense and hematopoiesis. It has been reported in the literature that IL-6 can induce the expression of IL-2 receptor and enhance the cytotoxic activity of PHA-stimulated cytotoxic T cells (CTL). This experiment observed IL-6 and IL-2 on human LAK cell induction and tumor-killing activity. (1) Inclusion of LAK cell clone in induction