用液中干燥法制备了含Ketoprofen的Eudragit-RS微型胶囊,为防止微囊的带电性和粘着性,在微囊化过程中,试用了数种硬脂酸金属盐作分散剂。结果表明,三硬脂酸铝用量少,所成微囊表面光滑,分散性好。用此法所制的微囊含量准确,具有明显的缓释作用,为制备Ketoprofen的长效或缓解制剂提供了新途径。 Eudragit-RS microcapsules containing Ketoprofen were prepared by a liquid-drying method. In order to prevent chargeability and adhesiveness of the microcapsules, several stearic acid metal salts were tested as a dispersant during the microencapsulation. The results show that the amount of aluminum tristearate is small, the microcapsules into a smooth surface, good dispersion. The microcapsule content prepared by this method is accurate and has obvious sustained-release effect, which provides a new way for preparing long-acting or relieving preparations of Ketoprofen.