目的:探讨生长抑素联合泮托拉唑钠治疗重症急性胰腺炎(SAP)的临床效果。方法:选取我院2011年1月至2014年1月收治的83例SAP患者,按随机数字表法分为两组,研究组42例,对照组41例。对照组患者在常规治疗基础上给予生长抑素治疗,研究组患者给予生长抑素联合泮托拉唑钠治疗。比较两组患者治疗疗效,并记录患者腹痛缓解时间、脱离呼吸机时间、肠道功能恢复时间、血淀粉酶恢复正常时间。结果:研究组总有效率为90.5%(38/42),明显高于对照组的75.6%(31/41),差异有统计学意义(P<0.05);研究组患者腹痛缓解时间、脱离呼吸机时间、肠道功能恢复时间及血淀粉酶恢复正常时间均明显短于对照组(P<0.05)。结论:生长抑素与泮托拉唑钠联合治疗SAP疗效显著,可有效改善患者临床症状,值得临床推广应用。 Objective: To investigate the clinical effect of somatostatin combined with pantoprazole sodium in the treatment of severe acute pancreatitis (SAP). Methods: Eighty-three patients with SAP who were admitted to our hospital from January 2011 to January 2014 were selected and divided into two groups according to the random number table: 42 in the study group and 41 in the control group. Patients in the control group were treated with somatostatin on the basis of routine treatment. Patients in the study group were treated with somatostatin plus pantoprazole sodium. The curative effect was compared between the two groups. The patients’ pain relief time, ventilator time, gut function recovery time and blood amylase recovery time were recorded. Results: The total effective rate was 90.5% (38/42) in the study group, which was significantly higher than that in the control group (75.6%, 31/41), the difference was statistically significant (P <0.05) Machine time, intestinal function recovery time and blood amylase recovery time were significantly shorter than the control group (P <0.05). Conclusion: The combination of somatostatin and pantoprazole sodium has a significant therapeutic effect on SAP, which can effectively improve the clinical symptoms and is worthy of clinical application.