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当ＨＰＭＣ骨架与水接触时，可以观察到水渗透进入ＨＰＭＣ骨架的过程。ＨＰＭＣ取代度类型对水渗透作用的影响集中表现在最初较短的一段时间内，这段时间是指ＨＰＭＣ形成水凝胶的时间。水凝胶形成后，水渗透进入凝胶的速率是恒定的。ＨＰＭＣ对水渗透作用的影响取决于其分子量。当ＨＰＭＣ骨架中加入药物后，水渗透进入骨架的能力会变弱。当水渗透进入ＨＰＭＣ骨架时，骨架可发生明显的膨胀，其轴向膨胀比径向膨胀大得多，骨架的膨胀主要由ＨＰＭＣ产生，骨架中ＨＰＭＣ含量越高，其膨胀程度越大。水渗透、骨架膨胀与药物释放之间存在线性相关性。
When the HPMC matrix is in contact with water, the infiltration of water into the HPMC matrix can be observed. The effect of the HPMC degree of substitution on water permeation is concentrated in the first short period of time, which is the time it takes for the HPMC to form a hydrogel. After hydrogel formation, the rate of water penetration into the gel is constant. The effect of HPMC on water infiltration depends on its molecular weight. When the drug is added to the HPMC matrix, the ability of the water to penetrate into the matrix becomes weaker. As water penetrates into the HPMC framework, the framework can undergo significant expansion with a much larger axial expansion than radial expansion. The swelling of the framework is mainly caused by the HPMC. The higher the HPMC content in the framework, the greater the swelling. There is a linear correlation between water infiltration, scaffold swelling and drug release.