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目的探讨高压氧联合依达拉奉、纳洛酮治疗急性一氧化碳(CO)中毒的疗效。方法 136例急性CO中毒患者,随机分为对照组及观察组,两组均采用高压氧治疗及其他如营养脑细胞、减轻脑水肿等的常规治疗,观察组在对照组治疗基础上加用依达拉奉和纳洛酮两种药物,评价两组治疗后疗效等。结果观察组在平均苏醒时间、疗效及迟发脑病发生例数等方面明显好于对照组(P<0.05)。结论高压氧联合依达拉奉、纳洛酮治疗急性CO中毒疗效确切,同时可明显减少并发症的发生。
Objective To investigate the efficacy of hyperbaric oxygen combined with edaravone and naloxone in the treatment of acute carbon monoxide poisoning. Methods One hundred and sixty-six patients with acute CO poisoning were randomly divided into control group and observation group. Both groups were treated with hyperbaric oxygen and other conventional therapy such as nutrient brain cells and cerebral edema. The observation group was treated with control group, Da Von and naloxone two drugs, to evaluate the efficacy of two groups after treatment. Results The observation group was significantly better than the control group in the mean recovery time, curative effect and the number of cases of delayed encephalopathy (P <0.05). Conclusion Hyperbaric oxygen combined with edaravone and naloxone in the treatment of acute CO poisoning is effective and can significantly reduce the incidence of complications.