论文部分内容阅读
目的探讨可溶性簇分化抗原26(s CD26)和二肽蛋白酶Ⅳ(DPP-Ⅳ)在良恶性胸腔积液鉴别诊断中的价值。方法收集良恶性胸腔积液患者各50例,其中上皮源恶性肿瘤35例,恶性间皮瘤5例,恶性淋巴瘤15例。采用酶联免疫吸附试验(ELISA)法检测胸腔积液的s CD26浓度和DPP-Ⅳ活性,比较s CD26和DPP-Ⅳ在不同胸腔积液中的差异。结果恶性胸腔积液组患者的s CD26、DPP-Ⅳ及癌胚抗原(CEA)水平明显高于良性胸腔积液;恶性胸腔积液组患者的腺苷脱氨酶(ADA)水平明显低于良性胸腔积液,差异均有统计学意义(P<0.05)。恶性间皮瘤患者的s CD26浓度明显高于上皮源恶性肿瘤、恶性淋巴瘤;恶性淋巴瘤患者的DPP-Ⅳ和ADA活性明显高于上皮源恶性肿瘤、恶性间皮瘤,差异均有统计学意义(P<0.05)。结论 s CD26和DPP-Ⅳ的检测对区分不同类型恶性胸腔积液有一定的辅助性临床参考价值。
Objective To investigate the value of sCD26 and DPP-Ⅳ in differential diagnosis of benign and malignant pleural effusions. Methods Fifty patients with benign and malignant pleural effusion were collected, including 35 epithelial-derived malignant tumors, 5 malignant mesothelioma and 15 malignant lymphoma. The concentrations of CD26 and DPP-Ⅳ in pleural effusion were detected by enzyme linked immunosorbent assay (ELISA), and the differences of sCD26 and DPP-Ⅳ in different pleural effusions were compared. Results The levels of CD26, DPP-Ⅳ and carcinoembryonic antigen (CEA) in patients with malignant pleural effusion were significantly higher than those in patients with benign pleural effusions. The levels of adenosine deaminase (ADA) in patients with malignant pleural effusion were significantly lower than those in benign Pleural effusion, the difference was statistically significant (P <0.05). Patients with malignant mesothelioma s CD26 concentration was significantly higher than epithelial-derived malignancies, malignant lymphoma; Malignant lymphoma in patients with DPP-Ⅳ and ADA activity was significantly higher than epithelial-derived malignant tumors, malignant mesothelioma, the difference was statistically significant Significance (P <0.05). Conclusion The detection of sCD26 and DPP-Ⅳ may be helpful to differentiate different types of malignant pleural effusions.