随着人类疾病谱的变化,恶性肿瘤已成为人类前三位的死亡原因之一,严重危害人类健康[1-2]。抗肿瘤治疗日益彰显其重要性。新的治疗手段及疗效特异性是当前医学界研究的热点[3-6]。苏云金芽胞杆菌(Bacillus thuringiensis,Bt)是一种昆虫病原细菌,其在营养生长期和芽孢形成期产生的伴孢晶体蛋白具有毒杀动植物寄生线虫的活性[7-11]。近年,有研究发现某些非杀虫活性的Bt能够产生抗癌 As the spectrum of human diseases changes, malignant tumors have become one of the top three causes of death in humans, which seriously endanger human health [1-2]. Anti-cancer treatment increasingly demonstrates its importance. The new treatment and efficacy specificity are the hot topics in the medical field [3-6]. Bacillus thuringiensis (Bt) is a kind of entomopathogenic bacterium. Its spore-forming crystal protein produced during vegetative growth and sporulation has the activity of killing plant parasitic nematodes [7-11]. In recent years, some studies have found that some non-insecticidal activity of Bt can produce anti-cancer