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目的:观察阿托伐他汀对原发性高血压颈动脉粥样硬化患者内膜中膜厚度的影响。方法:选取应用彩色多普勒超声仪检查发现有不同程度颈动脉粥样硬化斑块形成的患者82例,随机分为两组,治疗组45例,西药常规治疗基础上给阿托伐他汀20mg,每晚一次;对照组37例,对照组采用西药常规治疗,共6个月,观察两组治疗前后颈动脉内膜中膜厚度和斑块大小。结果:6个月后,治疗组颈动脉内膜中膜厚度和斑块,治疗前CIMT(mm):(1.52±0.30),治疗后CIMT(mm):(1.35±0.15),较治疗前明显缩小(P<0.05),对照组颈动脉内膜中膜厚度和斑块,治疗前CIMT(mm):(1.48±0.25),治疗后CIMT(mm):(1.46±1.20),治疗前后无明显差异(P>0.05)。结论:阿托伐他汀有明显稳定与消退斑块的作用。
Objective: To observe the effect of atorvastatin on intima-media thickness in patients with essential hypertension with carotid atherosclerosis. Methods: Eighty-two patients with different degrees of carotid atherosclerosis were examined by color Doppler sonography. They were randomly divided into two groups. The treatment group consisted of 45 cases. On the basis of conventional western medicine treatment, 20 cases of atorvastatin , Once a night; the control group of 37 cases, the control group with western medicine routine treatment, a total of 6 months, two groups before and after treatment of carotid intima-media thickness and plaque size. Results: After 6 months, carotid artery intima-media thickness and plaque, CIMT before treatment (mm) :( 1.52 ± 0.30), CIMT after treatment (mm) :( 1.35 ± 0.15) were significantly higher than those before treatment CIMT (mm): (1.48 ± 0.25), CIMT (mm) after treatment: (1.46 ± 1.20), no significant difference between before and after treatment (P <0.05) Difference (P> 0.05). Conclusion: Atorvastatin has obvious effect of stabilizing and resolving plaques.