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目的观察顺铂联合白介素-2胸腔灌注治疗恶性胸腔积液的临床疗效和毒副反应。方法采用胸腔闭式引流术,观察组在胸腔内注入顺铂60mg、白介素-2100万U,对照组在胸腔内注入顺铂60mg。每周1次,共1～3次。观察疗效、生活质量、生存率和毒副反应。结果观察组有效率为81.82%,照组有效率为55.00%,差异有显著性(P<0.05)。两组无严重不良反应,均可耐受。结论顺铂和白介素-2联合胸腔内注射,消除胸水作用明显,值得临床推广。
Objective To observe the clinical efficacy and side effects of cisplatin and interleukin-2 in the treatment of malignant pleural effusion. Methods Thoracic closed drainage was used. The observation group received cisplatin 60 mg and interleukin-21 million U in the thoracic cavity. The control group received cisplatin 60 mg intrathoracically. 1 times a week, a total of 1 to 3 times. Observation of efficacy, quality of life, survival and toxicity. Results The effective rate was 81.82% in observation group and 55.00% in effective group, the difference was significant (P <0.05). Two groups without serious adverse reactions, can be tolerated. Conclusions Cisplatin and interleukin-2 combined with intrathoracic injection have obvious effect of eliminating pleural effusion, which is worthy of clinical promotion.