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1995年10月至1997年10月在湖北省石首市3个村采用队列研究方法进行了本研究．基线粪检阳性者行吡喹酮治疗后7个月复查，阴转者作为再感染观察队列。第1队列＜20岁组159人观察了1个传播期，再感染率（RIR）为34．59％（55／159）．对23项有关因素进行了单因素分析，并对其中有显著意义的10项因素作Logistic回归模型拟合，结果特异抗体IgE／IgG_4比值、基线感染度、疫水接触指数、住址距堤境距离、血中嗜酸性粒细胞计数和近期化疗等6项因素进入模型．第2队列观察260人（＜20岁77人，≥20岁183人），主要进行两年龄组再感染水平及免疫因素的比较．结果＜20岁组期中、期终RIR和全观察期累积RIR分别为37．66％、28．57％和66．23％，均明显高于≥20岁组的20．77％、16．39％和37．16％（P＜0．05）．影响RIR年龄分布因素分析发现，＜20岁组期中、期终IgE的OD值均值明显低于≥20岁组，IgG_4的OD值均值则明显高于≥20岁组、IgE／IgG_4比值均值前一组明显低于后一组．基线感染度高低也与再感染（RI）有关．但期中和期终前组疫水接触指数等级均明显低于后一组（P＜0．01）．研究结果认为，儿童青少年再感染危险性较高，主要原因可能与特异性抗力发展缓慢有关，作者强调，IgE／IgG_4比值低是指示易感性极为重要的?
From October 1995 to October 1997, a cohort study was conducted in three villages in Shishou City, Hubei Province. Baseline fecal seizure positive praziquantel treatment 7 months after the review, negative conversion to re-infection as a cohort. In the first cohort, 159 people in the 20-year-old group observed one transmission period with a re-infection rate (RIR) of 34.59% (55/159). Univariate analysis was carried out on 23 related factors and 10 significant factors were fitted to Logistic regression model. The results showed that IgE / IgG 4 ratio of specific antibody, baseline infection, water contact index, address distance from embankment , Blood eosinophil count and recent chemotherapy and other six factors into the model. In the second cohort, 260 patients (77 in <20 years and 183 in ≥20 years) were observed. The level of re-infection in the two age groups and the comparison of immune factors were compared. Results In the 20-year-old group, the RIR at the end of the period and the cumulative observation period were 37.66%, 28.57% and 66.23%, respectively, which were significantly higher than those of the 20-year-old group (20.77%, 16.39% % And 37.16% respectively (P <0.05). The analysis of the influencing factors of age distribution of RIR found that mean OD value of end-stage IgE was significantly lower than that of ≥20-year-old in the age of 20 years, mean OD value of IgG_4 was significantly higher than that of ≥20 years old, IgE / Group was significantly lower than the latter group. The level of baseline infection is also associated with re-infection (RI). However, the contact index of water in the middle and end of the period was significantly lower than the latter group (P <0.01). The study concluded that children and adolescents with a higher risk of re-infection, the main reason may be related to the slow development of specific resistance, the author stressed that, IgE / IgG4 low ratio is indicative of susceptibility is extremely important?