Objective: To explore the expression of c-Myb gene in the bone marrow cell of irradiated mice treated with rhBMP- and its significance. Methods: By way of RT-PCR and RNA dot blot, we observed the expression of c-Myb gene in the bone marrow cells of mice treated differently on day 10 and day 20 after irradiation respectively. Results: On day 10 after irradiation, the expression of c-Myb gene in the bone marrow cell ofirradiated mice treated with rhBMP-2m is evidently higher than that in normal mice, and also higher than that only treated with irradiation. However, on day 20 after irradiation, there are no evident differences in the three groups. Conclusion: c-Myb gene takes part in the recovery of hematopoiesis during the stage of acute recovery in bone marrow after irradiation, and the effect is enhanced in the participation of rhBMP-2m.