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目的:比较黄芪、川芎嗪注射液加免疫化学治疗(治疗组)与单纯免疫化学疗法(对照组)对转移性肾癌的疗效。方法:对照组18例,进行免疫化学治疗。白介素2(IL-2)5~20MU,每周3次皮下注射、干扰素(IFN-α)6~9MU每周3次皮下注射、氟尿嘧啶(5-Fu)每次500~750mg静脉滴注,1~5d。治疗组18例,在对照组方案的基础上同时加用川芎嗪注射液320mg、黄芪注射液20ml溶于生理盐水250ml中每天1次。连用28d为1个周期,所有病人均接受3个周期以上的治疗。结果:治疗组有效率50%,对照组33.3%;治疗组肿瘤进展率5.6%对照组27.8%。两组比较有统计学差异(P<0.05)。结论:黄芪、川芎嗪注射液与免疫化学药物联用治疗转移性肾癌是有效的手段。
Objective: To compare the curative effect of Radix Astragali, Ligustrazine Injection plus immunochemotherapy (treatment group) and immunosuppressive chemotherapy alone (control group) on metastatic renal cell carcinoma. Methods: The control group of 18 cases, immunochemotherapy. Interleukin 2 (IL-2) 5 ~ 20MU, 3 times a week subcutaneous injection of interferon (IFN-α) 6 ~ 9MU subcutaneous injection of 3 times per week, 5-Fu each 500 ~ 750mg intravenous drip, 1 ~ 5d. Treatment group of 18 cases, in the control group on the basis of the program plus ligustrazine injection 320mg, Astragalus injection 20ml dissolved in normal saline 250ml once daily. 28d for the use of a cycle, all patients received more than three cycles of treatment. Results: The effective rate was 50% in the treatment group and 33.3% in the control group. The rate of tumor progression in the treatment group was 5.6% and that in the control group was 27.8%. There was a significant difference between the two groups (P <0.05). Conclusion: Astragalus and ligustrazine injection combined with immunochemical drugs in the treatment of metastatic renal cell carcinoma is an effective means.