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日本东京消息:东京Jikei医学院研究人员报告说,已发现钙拮抗剂硫氮(艹卓)酮(Diltiazem)对预防高胆固醇饲养的大白鼠动脉粥样硬化有效。这是最近几个月证明钙通道拮抗剂具有抗动脉粥样硬化作用的第二次动物研究报告。钙通道拮抗剂通常是用于控制心绞痛病人的冠状血管痉挛。成尾多田及同事以4种不同的饮食对鼠进行了试验:即正常饮食:高胆固醇饮食;高胆固醇饮食加66mg/kg/天的硫氮(艹卓)酮或高胆固醇饮食加200mg/kg/天的硫氮(艹卓)酮。
TOKYO, Japan: Researchers from Tokyo’s Jikei Medical School reported that calcium-antagonist Diltiazem has been found to be effective in preventing atherosclerosis in rats raised in high cholesterol. This is the second animal study that has proven anti-atherogenic effects of calcium channel blockers in recent months. Calcium channel blockers are commonly used to control coronary vasospasm in angina patients. Shibata Tada and colleagues tested the rats with four different diets: normal diet: a high cholesterol diet; a high cholesterol diet plus 66 mg / kg / day of sulphonylurea or a high cholesterol diet plus 200 mg / kg / Day of sulfur nitrogen (艹 Zhuo) ketone.