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河北省 1 997～ 2 0 0 2年急性弛缓性麻痹 (AFP)病例病毒学监测中 ,共有 2 0 2例分离到非脊髓灰质炎肠道病毒(NPEV) ,年均NPEV分离率 1 0 1 %。对分离到的NPEV毒株进行了型别鉴定 ,在明确定型的 1 0 3株NPEV中 ,包括柯萨奇病毒 (Coxsackievirus ,Cox )A组 1个型 ;Cox B组 5个型 ;埃可病毒 (ECHO) 1 4个型。RD细胞对ECHO和Cox A9敏感 ,HEp 2细胞对Cox B敏感。取消HEp 2细胞的使用 ,会造成多数Cox B和一些未能定型的NPEV漏检 ,使NPEV分离率明显降低。NPEV感染有明显的夏秋季高峰 ,主要集中在小年龄组儿童 ,以 1岁和 2岁为多。
A total of 202 isolates of non-polio enterovirus (NPEV) were isolated from virulent surveillance of acute flaccid paralysis (AFP) cases from 1997 to 2002 in Hebei Province. The average annual NPEV isolation rate was 101% . The type of NPEV isolates were identified. Of the 103 well-characterized NPEVs, 1 was in group A, Coxsackievirus (Cox), 5 were in group Cox B, (ECHO) 1 4 types. RD cells are sensitive to ECHO and Cox A9, and HEp 2 cells are sensitive to Cox B. Removal of HEp 2 cells resulted in a significant reduction in NPEV isolation for most Cox B and some undetected NPEVs. NPEV infection has a significant peak in summer and autumn, mainly concentrated in children of small age group, 1 year old and 2 years old.