日本血吸虫病感染的慢性期T细胞对虫卵抗原的应答受到抑制。这种现象与本病的临床症状密切相关,因为日本血吸虫病特征性的肝脾病变本质上是栓塞于肝内门脉支的虫卵周围形成肉芽肿,这一反应是T细胞控制下的宿主应答。T细胞反应的调节机制已知有抑制性T细胞(Ts)介导的和抗基因型抗体(抗Id)介导的两种。预防日本血吸虫病的感染很困难,目前正着眼于通过阐明T细胞应答的控制机制,研究即便感染也不发病,即所谓病理学预防接种的司能性。作者等在体外以可溶性虫卵抗原(SEA)刺激慢性日本血吸虫病患者末梢血中的T细 Chronic T cells infected with Schistosoma japonicum have a suppressed response to the egg antigen. This phenomenon is closely related to the clinical symptoms of this disease because the characteristic hepatic and splenic lesions of Schistosoma japonicum are essentially granulomas formed around the eggs of the hepatic portal vein, a response under the control of T cells answer. Regulatory mechanisms of T-cell responses are known to be both T-cell mediated (Ts) and anti-idiotypic (anti-Id) -mediated. Prevention of schistosomiasis japonica infection is difficult, is now looking at clarifying the control mechanism of T cell responses to study even if the infection does not occur, the so-called pathology vaccination Secretary Division. In vitro stimulation of T-lymphocytes in peripheral blood of patients with chronic schistosomiasis by soluble egg antigen (SEA)