目的 :探讨术前血清C反应蛋白 (CRP)水平对冠状动脉支架置入术后主要心血管事件 (MACE)的预测价值。方法 :术前测定 6 5例连续行直接经皮冠状动脉介入干预 (PCI)术患者 [31例稳定型心绞痛 (SAP)和 34例急性冠脉综合征 (ACS) ]血清CRP水平。将患者分为CRP <3.0mg l(30例 )和CRP≥ 3.0 (35例 )两组 ,观察患者临床特征 ,并随访 7.0± 3.5个月主要心血管事件。结果 :术前血清CRP水平在ACS比SAP组高 [(12 .6± 4 .2 )比 (4 .8± 1.2 )mg l,P <0 .0 1];术后随访 7.0± 3.5个月的主要心血管事件发生率CRP高者远高于CRP低者 (2 5 .7%比 10 .0 % ,P <0 .0 1)。结论 :术前血清CRP水平是冠状动脉病变支架置入术后主要心血管事件的预测指标。这提示术后主要心血管事件发生率和支架置入术前炎症细胞活化程度密切相关 Objective: To investigate the predictive value of preoperative serum C-reactive protein (CRP) level in major cardiovascular events (MACE) after coronary stenting. Methods: Serum CRP levels were measured preoperatively in 65 consecutive patients undergoing percutaneous coronary intervention (PCI) [31 patients with stable angina (SAP) and 34 patients with acute coronary syndrome]. The patients were divided into two groups: CRP <3.0 mg l (30 cases) and CRP≥3.0 (35 cases). The clinical features of the patients were observed and followed up for 7.0 ± 3.5 months of major cardiovascular events. Results: Preoperative serum CRP levels were significantly higher in patients with ACS than those in patients with SAP [(12.6 ± 4.2) vs (4.8 ± 1.2) mg l, P <0.01]; postoperative follow-up was 7.0 ± 3.5 months The incidence of major cardiovascular events was significantly higher in CRP than in those with lower CRP (25.7% vs. 10.0%, P <0.01). Conclusions: Preoperative serum CRP level is a predictor of major cardiovascular events after stent implantation in patients with coronary artery disease. This suggests that the incidence of postoperative major cardiovascular events is closely related to the degree of inflammatory cell activation before stent implantation