在英国,不需要用胰岛素的成人型糖尿病采用双胍类-降糖灵及 metformin 治疗已近20年。这些药物是通过降低糖的吸收,增加糖的酵解及减少丙氨酸、丙酮酸盐、乳酸盐的糖原异生来降低血糖浓度的、因此它们引起血中乳酸盐浓度升高是不可避免的。降糖灵远远比 m-efformin 更能使血中乳酸盐浓度升高,但很少超过2毫克分子(正常范围0.4-1.3毫克分子)。 In the UK, biguanides - hypoglycemic agents and metformin have not been used in adults with insulin for nearly 20 years. These drugs lower blood glucose levels by reducing the absorption of sugars, increasing glycolysis, and reducing gluconeogenesis in alanine, pyruvate and lactate, so they do not raise the blood lactate concentration Avoided. Hypoglycemic is far more effective than m-efformin in increasing the blood lactate concentration, but seldom exceeds 2 milligrams (normal range 0.4-1.3 milligram).