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本文首次报道了人白细胞干扰素(Le IFN)对人轮状病毒的作用。体外实验表明,MA104细胞对人Le IFN敏感,人Le IFN能抑制轮状病毒Wa株对MA104细胞的致病作用。临床观察说明低剂量的粗制白细胞干扰素(5万IU/ml)对轮状病毒胃肠炎有明显的疗效,与常规对症治疗比较,肌注组不论在全病程或用药后治愈天数上均有极明显的缩短(P<0.001),但有发热的付作用。灌肠组亦有显著的疗效(P<0.01),虽逊于肌注组,但无明显付作用。本文建议用部分纯化IFN肌注可能会减少付反应或加大粗IFN的灌肠剂量可望提高疗效。
This paper reports for the first time the effect of human leukocyte interferon (Le IFN) on human rotavirus. In vitro experiments show that, MA104 cells are sensitive to human Le IFN, human Le IFN can inhibit rotavirus Wa strain on the pathogenic role of MA104 cells. Clinical observations show that low-dose crude interferon-γ (50,000 IU / ml) has a significant effect on rotavirus gastroenteritis. Compared with the conventional symptomatic treatment, intramuscular injection group showed no significant difference in the duration of treatment or days after treatment Significantly shortened (p <0.001), but with fever. Enema group also had a significant effect (P <0.01), although less than intramuscular injection group, but no significant role. This article suggests that partially purified IFN intramuscular injection may reduce the response or increase the dose of crude IFN enema expected to improve the efficacy.