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已知肝细胞内游离Ch含量对LDL受体有调节作用,对其他调节机制所知甚少。近来,获得了许多巨噬细胞(Mφ)调节肝功能和脂蛋白代谢的体内证据。本文研究了Mφ条件培养基或纯化的Mφ分泌的蛋白质对人肝肿瘤细胞株HepG_2的LDL受体的影响。 LPS激活的小鼠腹腔Mφ和人类单核Mφ条件
It is known that the free Ch content in hepatocytes has a regulatory effect on LDL receptors and little is known about other regulatory mechanisms. Recently, a large body of evidence of macrophage (Mφ) regulation of liver function and lipoprotein metabolism has been obtained. In this paper, the effects of Mφ conditioned medium or purified Mφ secreted protein on LDL receptor of human hepatocarcinoma cell line HepG_2 were studied. LPS-activated mouse peritoneal Mφ and human mononuclear Mφ conditions