论文部分内容阅读
五味子酚(五酚)可抑制Fe-半胱氨酸引起的微粒体、线粒体脂质过氧化。五酚还具有直接清除活性氧自由基的能力。广谱抗肿瘤药阿霉素的心脏毒性主要是由于其在心肌线粒体中产生活性氧自由基、主要是羟基自由基(OH)所致。由阿霉素产生的OH可攻击线粒体引起膜脂质过氧化,膜流动性下降以及酶失活。本文研究了五酚对阿霉素引起的线粒体毒性的保护作用。ESR波谱观察到,在NADH作用下,阿霉素可在线粒体中获得电子产生阿霉素半醌自由基(AQ)(g=2.0024)。在该条件下加入H_2O_2和DMPO(5,5-dimethyl-
Schisandra phenol (five phenol) can inhibit Fe-cysteine-induced microsomal mitochondrial lipid peroxidation. Five phenol also has the ability to directly scavenge reactive oxygen species. The cardiotoxicity of the broad-spectrum antitumor drug doxorubicin is mainly due to its production of reactive oxygen species in the mitochondria of myocardium, mainly due to hydroxyl radicals (OH). OH, produced by doxorubicin, can attack mitochondria causing membrane lipid peroxidation, decreased membrane fluidity, and enzyme inactivation. This paper studied the protective effect of pentoloxifene against doxorubicin-induced mitochondrial toxicity. ESR spectroscopy observed that doxorubicin produced an electron-rich doxorubicin free radical (AQ) in the mitochondria (g = 2.0024) under the action of NADH. Under this condition, H 2 O 2 and DMPO (5,5-dimethyl-