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探讨监测肝纤维化程度敏感的血清学指标。方法：采用ＥＬＩＳＡ双抗体夹心法，对４０名正常人及 １２５例肝病患者血清肿瘤坏死因子－α（ＴＮＦ－α）、Ⅳ型胶原含量进行了测定。结果：慢性迁延性肝炎（慢迁肝）组、慢性 活动性肝炎（慢活肝）组、肝硬化组血清 ＴＮＦ－α、 Ⅳ型胶原分别显著高于正常对照组和急性黄疸性肝炎（急黄肝）组 （均Ｐ＜０．０１），其中肝硬化组较慢迁肝组、慢活肝组又显著升高（Ｐ＜０．０１），而急黄肝组与正常对照组比较差异无显 著性（Ｐ＞０．０５）。结论：随肝纤维化进展，血清ＴＮＦ－α、Ⅳ型胶原水平均呈上升趋势，验证了肝纤维化程度与Ⅳ型胶 原间定量关系，且发现ＴＮＦ－α可能为反映肝纤维化程度的又一个良好指标。
To explore the degree of susceptibility to monitoring of liver fibrosis serological indicators. Methods: The levels of serum tumor necrosis factor-α (TNF-α) and type Ⅳ collagen in 40 normal subjects and 125 patients with liver disease were determined by ELISA double antibody sandwich method. Results: The levels of TNF-α and Ⅳ collagen in chronic active hepatitis (chronic liver metastasis) group, chronic active hepatitis (chronic liver disease) group and cirrhosis group were significantly higher than those in normal control group and acute jaundice hepatitis (All P <0.01). The rates of liver cirrhosis group and chronic liver group were significantly increased (P <0.01), while the differences between acute yellow liver group and normal control group were no significant difference Significance (P> 0.05). CONCLUSIONS: With the progress of liver fibrosis, serum TNF-α and type Ⅳ collagen levels are on the rise, verifying the relationship between the degree of liver fibrosis and type Ⅳ collagen, and found that TNF-α may reflect the degree of liver fibrosis A good indicator.