据报道很多种药物通过各种发病机制引起胆囊疾病。早期的流行病学研究表明,口服避孕药的妇女患胆囊疾病的危险性增加1倍。然而,近期的研究未能支持上述结论,这些矛盾的结果可能是由于确定胆囊疾病所使用的方法不同。但在妇女口服避孕药期间,其胆汁中的结石形成指数增加,这是由于雌激素增加肝细胞对脂蛋白的摄取,导致胆汁中胆固醇的高分泌;孕酮能抑制乙酰辅酶A-胆固醇酰基转移酶(ACAT)的活性,使胆固醇不能很快转变成为胆固醇醋。降血脂药物中只有氯贝特有增加胆结石形成的危险。其它纤维酸(fibric acid)衍生物有类似的性质,但临床经验还不广泛。这些衍 A variety of drugs have been reported to cause gallbladder disease through a variety of pathogenesis. Early epidemiological studies showed that women who took oral contraceptives doubled the risk of gallbladder disease. However, recent studies failed to support the above conclusion, and these contradictory findings may be due to the different methods used to determine gallbladder disease. However, during oral contraceptives in women, the stones in the bile form an exponential increase due to increased estrogen uptake of lipoproteins by the liver cells leading to the high secretion of cholesterol in bile; progesterone inhibits acetyl-CoA-cholesterol acyl transfer Enzyme (ACAT) activity, so that cholesterol can not be quickly converted into cholesterol vinegar. Only clofibrate in hypolipidemic drugs may increase the risk of gallstone formation. Other fibric acid derivatives have similar properties, but clinical experience is not extensive. These Yan