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[目的]探讨柴胡桂枝汤(CHGZT)促进泌酸腺再生的作用机制。[方法]对比观察大鼠乙酸胃溃疡形成后3个时间段胃体黏膜、再生黏膜表皮生长因子受体(EGFR)的表达及CHGZT对其的影响。[结果]EGFR表达于胃体黏膜泌酸腺的壁细胞以及再生黏膜CHGZT溃疡伴随细胞系(UACL)中的去分化或再分化壁细胞;在溃疡形成后的3个时间段,与模型对照组和西咪替丁组相比,CHGZT组溃疡边缘胃体侧正常黏膜以及再生黏膜EGFR的表达均增多,其差异具有统计学意义(均P<0.01)。[结论]CHGZT促进泌酸腺再生,其机制可能与其促进溃疡附近胃体黏膜以及再生黏膜EGFR的表达有关。
[Objective] To explore the mechanism of promoting regeneration of oxyntic acid secretion by Chaihu Guizhi Decoction (CHGZT). [Methods] The expression of epidermal growth factor receptor (EGFR) in gastric mucous membrane and regenerated mucous membrane and the effect of CHGZT on it were observed in three different periods after the formation of acetic acid gastric ulcer in rats. [Results] EGFR was expressed in the parietal cells of the mucous glands of the gastric mucosa and the dedifferentiation or redifferentiation of parietal cells in the concomitant cell line (UACL) of the regenerative mucosa CHGZT ulcer; in the three time periods after ulcer formation, the model control group Compared with the cimetidine group, the expression of EGFR in normal mucosa and regenerative mucosa in the margin of the ulcer in the CHGZT group increased, and the difference was statistically significant (all P<0.01). [Conclusion] CHGZT promotes the regeneration of oxyntic acid glands, and its mechanism may be related to the promotion of the expression of gastric epithelial mucosa and EGFR in regenerated mucosa around ulcers.