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目的:探讨泮托拉唑治疗消化性溃疡出血的疗效。方法:将62例消化性溃疡伴急性上消化道出血患者随机分为两组:治疗组采用泮托拉唑治疗,对照组采用西咪替丁治疗。结果:泮托拉唑组48h出血停止,有效率为93.5%,平均止血时间(2±0.5)d;西咪替丁组48h出血停止,有效率为67.7%,平均止血时间(4.5±0.5)d。两组比较有统计学差异(P<0.01或P<0.05)。结论:泮托拉唑治疗消化性溃疡伴急性上消化道出血疗效优于西咪替丁,且无明显不良反应。
Objective: To investigate the efficacy of Pantoprazole in the treatment of peptic ulcer bleeding. Methods: 62 cases of peptic ulcer with acute upper gastrointestinal bleeding were randomly divided into two groups: the treatment group was treated with pantoprazole, the control group was treated with cimetidine. Results: The bleeding in the pantoprazole group was stopped at 48h, the effective rate was 93.5% and the mean bleeding time was (2 ± 0.5) d. The cimetidine group stopped bleeding at 48h, the effective rate was 67.7% and the mean bleeding time was 4.5 ± 0.5 d. There was a significant difference between the two groups (P <0.01 or P <0.05). Conclusion: Pantoprazole is superior to cimetidine in the treatment of peptic ulcer with acute upper gastrointestinal bleeding without obvious adverse reactions.