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目的探讨百令胶囊对狼疮性肾炎(lupus nephritis,LN)患者白介素-2(interleukin-2,IL-2)、补体及感染率的影响。方法将120例LN患者随机分成观察组和对照组,每组60例。2组常规治疗相同,观察组给予百令胶囊(每次1 g,每天3次)治疗,比较2组治疗12个月临床疗效、感染率、IL-2、补体C3及药物不良反应情况。结果治疗12个月,与对照组相比,观察组IL-2、补体C3和血白蛋白显著升高,尿蛋白、尿红细胞和SLEDAI显著降低,差异均有统计学意义(P<0.05)。观察组有效率(88.33%)显著高于对照组(71.67%),感染率(21.67%)显著低于对照组(45.00%),差异均有统计学意义(P<0.05)。2组不良反应发生率比较,差异无统计学意义。结论百令胶囊通过调节IL-2和补体C3水平提高LN的临床疗效,降低感染率,且不增加药物不良反应。
Objective To investigate the effect of Bailing capsule on interleukin-2 (IL-2), complement and infection rate in patients with lupus nephritis (LN). Methods 120 patients with LN were randomly divided into observation group and control group, 60 cases in each group. The two groups were given the same routine treatment. The observation group was treated with Bailing capsule (1 g each time, 3 times a day). The clinical efficacy, infection rate, IL-2, complement C3 and adverse drug reaction were compared between the two groups for 12 months. Results Compared with the control group, the levels of IL-2, complement C3 and serum albumin in the observation group were significantly increased, while the levels of urinary protein, urinary erythrocyte and SLEDAI were significantly decreased in the 12-month treatment group (P <0.05). The effective rate of observation group (88.33%) was significantly higher than that of control group (71.67%), infection rate (21.67%) was significantly lower than that of control group (45.00%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in the two groups, the difference was not statistically significant. Conclusion Bailing capsule can improve the clinical efficacy of LN by regulating the levels of IL-2 and complement C3, reduce the infection rate, and do not increase the adverse drug reactions.