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目的:寻求中期引产安全、有效、副作用及并发症少的引产方法。方法:230例妊娠14～26周,年龄17～40岁的妇女,随机分为观察组和对照组各115例。观察组第1天空腹口服米非司酮100 mg,24h后常规行依沙吖啶羊膜腔注射引产,两组常规行清宫术。结果:观察组113例自然排胎,引产成功率98.26%,对照组92例自然排胎,引产成功率80%;宫颈成熟情况:观察组显效103例,有效10例,无效2例,总有效率98.26%,对照组显效57例,有效35例,无效23例,总有效率80%;引产时间:观察组(33.2±3.17)h,对照组(45.8±3.83)h;胎盘残留情况:观察组平均(23±11.5)g,对照组(57±16.5)g;产后出血情况:观察组产后2h出血量小于150ml者111例,大于150ml者4例,引产后出血时间为(7.55±3.58)天,对照组产后2h出血量小于150ml者110例,大于150ml者5例,引产后出血时间为(8.20±3.67)天。结论:米非司酮配伍依沙吖啶,因其引产机制相互补充,可起到协同作用,弥补了单一使用依沙吖啶终止中期妊娠引起的胎盘、胎膜残留,宫颈损伤发生率高的缺陷,有效地降低了并发症的发生,提高了中期引产术的安全性。
Objective: To seek midwiful labor safe, effective, fewer side effects and complications of induction of labor. Methods: 230 pregnant women 14 to 26 weeks of gestation, aged 17 to 40 years old were randomly divided into observation group and control group of 115 cases. On the first day of the observation group, oral administration of mifepristone was given 100 mg a day for 24 hours. The patients were randomly assigned to receive amniotic fluid injection of amniotic fluid in the amniotic cavity. Histopathology was performed in both groups. Results: The natural rowing of 113 cases in the observation group was successful. The successful rate of induction of labor was 98.26% in the observation group and 92 cases of natural rowing in the control group. The successful rate of induction of labor was 80%. In the cervical ripening group, 103 cases were markedly effective, 10 cases were effective and 2 cases were ineffective. The effective rate was 98.26% in the control group, 57 in the control group, 35 in the effective group and 23 in the ineffective group, with a total effective rate of 80%. The induction rate was 33.2 ± 3.17 h in the observation group and 45.8 ± 3.83 h in the control group. (23 ± 11.5) g in the control group and 57 ± 16.5 g in the control group. Postpartum hemorrhage was observed in 111 cases in the observation group with blood loss of less than 150ml at 2h postpartum, 4 cases of more than 150ml in the observation group, and 7.55 ± 3.58 days after the induction of labor. Day, control group 2h postpartum hemorrhage less than 150ml in 110 cases, more than 150ml in 5 cases, postpartum hemorrhage time (8.20 ± 3.67) days. Conclusion: Mifepristone combined with ethacridine can synergistically complement each other because of the induction of labor mechanism, and make up for the single use of ethacridine to terminate the placenta, residual fetal membranes and high incidence of cervical injury caused by metaphase pregnancy Defects, effectively reducing the incidence of complications and improve the safety of mid-term induction of labor.