5-脂氧合酶(5-LO)是白三烯(LT)和5-HETE(5-羟基花生四烯酸)生物合成过程中的关键酶,而白三烯是炎症、变应性及梗阻性疾病中的重要介质,因此寻找5-LO抑制剂成为有关研究的目标。但体外5-LO抑制剂很难在体内产生作用,可能是因为药物的生物利用度低,副作用较大或氧化条件下失活。乳香树脂是经有机溶剂提取后的混 5-lipoxygenase (5-LO) is a key enzyme in the biosynthesis of leukotrienes (LT) and 5-HETE (5-hydroxyarachidonic acid), and leukotrienes are inflammatory, allergic and Important mediators in obstructive diseases, so the search for 5-LO inhibitors has become the target of relevant research. However, in vitro 5-LO inhibitors are difficult to produce in vivo, probably because of low bioavailability of drugs, greater side effects, or inactivation under oxidative conditions. Mastic is a mixture of organic solvents