我们和其他作者曾相继发现在血清成分的参与下,内毒素显著刺激猪主动脉内皮细胞前列环素(PGI_2)的生成。PGI_2是花生四烯酸的代谢产物。花生四烯酸在合成PGI_2的过程中,首先经环氧化酶催化,形成不稳定的前列腺素内过氧化物-PGG_2和PGH_2。后者再在前列环素合成酶的作用下产生 PGI_2。Suttorp 等通过系列研究证实内 We and other authors have successively found that endotoxin significantly stimulates the production of prostacyclin (PGI_2) in porcine aortic endothelial cells with serum components. PGI_2 is a metabolite of arachidonic acid. Arachidonic acid in the synthesis of PGI_2 process, first by cyclooxygenase-catalyzed formation of unstable prostaglandin endoperoxide-PGG_2 and PGH_2. The latter produces PGI_2 under the action of prostacyclin synthase. Suttorp et al confirmed by a series of studies