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阿片肽对老龄动物脾淋巴细胞丝裂原反应性的影响,迄今作者只检索到1篇文献(1988),该文作者观察到老龄可降低β-内啡肽(β-endorphin,β-END)增强丝裂原诱导的细胞增殖作用。本实验选用不同浓度的甲硫脑啡肽(methionine enkephalin,MENK)和β-END,分别作用于PHA激活的老龄Wistar大鼠脾淋巴细胞,探索两类阿片肽对老龄大鼠脾淋巴细胞的作用,观察年龄对中枢神经内分泌调节免疫功能的影响。此外,本实验还观察阿片肽对巨噬细胞吞噬作用的影响,以便全面了解阿片肽和免疫功能的关系。
Opioid peptides on aging animals spleen lymphocytes mitogen-induced reactivity, so far the author only retrieved one article (1988), the authors observed that aging can reduce β-endorphin (β-ENDorphin, β-END) Enhance mitogen-induced cell proliferation. In this experiment, different concentrations of methionine enkephalin (MENK) and β-END were used in splenic lymphocytes of aged Wistar rats with PHA activation to explore the effects of two types of opioid peptides on splenic lymphocytes of aged rats , To observe the impact of age on central nervous endocrine regulation of immune function. In addition, this experiment also observed opioid phagocytosis of macrophages in order to fully understand the relationship between opioid and immune function.