论文部分内容阅读
用循环线性电流扫描计时电位法(CLC)、循环伏安法(CV)和微分脉冲伏安法(DPV)研究了五种胆碱类药物在水/硝基苯界面(W/NB)上的转移行为.在水相溶液呈碱性时,观察到了伴有不可逆水解反应的相转移过程.讨论了药物结构中的取代基效应,并依据离子转移的标准 Gibbs 能△_o~wG_(tr)~o 度量了取代基的疏水性效应及药物的脂溶性.
The effects of five choline drugs on the water / nitrobenzene interface (W / NB) were investigated by cyclic linear current sweep chronopotentiometry (CLC), cyclic voltammetry (CV) and differential pulse voltammetry (DPV) Transfer behavior was observed.When the aqueous solution was alkaline, the phase transfer process with irreversible hydrolysis reaction was observed.The substituent effect in the drug structure was discussed and the Gibbs energy △ _o ~ wG_ (tr) ~ o Measure the hydrophobic effect of the substituent and the lipid solubility of the drug.