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目的:探讨酚妥拉明与硫酸镁联合在妊娠期高血压疾病(PIH)治疗中的临床效果。方法:选择仙居县妇幼保健院2013年1~6月治疗的PIH患者100例,随机分为对照组及观察组各50例。对照组应用酚妥拉明治疗PIH患者,观察组应用酚妥拉明与硫酸镁联合治疗。比较两组治疗前后收缩压(SBP)、舒张压(DBP)改善情况及临床治疗有效率,同时比较两组患者在治疗过程中的药物不良反应发生率。结果:①两组治疗前SBP、DBP比较差异无统计学意义(P>0.05),经15天治疗后两组SBP及DBP较同组治疗前均显著改善,且观察组治疗15天后SBP[(114.08±12.49)mmHg]及DBP[(91.04±8.86)mmHg]均低于对照组[(139.24±15.84)、(99.88±8.97)mmHg],差异均有统计学意义(P<0.05)。②观察组治疗总有效率[88.00%(44/50)]显著高于对照组[66.00%(33/50)],差异有统计学意义(χ2=5.482 4,P<0.05)。③观察组与对照组在15天的治疗时间内药物不良反应发生率比较[14.00%(7/50)比18.00%(9/50)]差异无统计学意义(χ2=0.297 6,P>0.05)。结论:酚妥拉明与硫酸镁联合治疗PIH可显著提高治疗效果且不提高药物不良反应发生率。
Objective: To investigate the clinical effect of phentolamine combined with magnesium sulfate in the treatment of hypertensive disorders of pregnancy (PIH). Methods: 100 cases of PIH patients treated in Xianju Maternal and Child Health Hospital from January to June, 2013 were randomly divided into control group and observation group of 50 cases each. The control group was treated with phentolamine in patients with PIH. The observation group was treated with phentolamine and magnesium sulfate. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) were compared between the two groups before and after treatment, and the effective rate of clinical treatment was compared. Meanwhile, the incidence of adverse drug reactions in the two groups was compared. Results: ① There was no significant difference in SBP and DBP between the two groups before treatment (P> 0.05). SBP and DBP in two groups after 15 days treatment were significantly improved compared with those in the same group before treatment, and SBP [( (114.08 ± 12.49) mmHg and DBP (91.04 ± 8.86 mmHg) were significantly lower than those in the control group (139.24 ± 15.84 and 99.88 ± 8.97 mmHg, respectively) (P <0.05). ② The total effective rate in the observation group [88.00% (44/50)] was significantly higher than that in the control group [66.00% (33/50)]. The difference was statistically significant (χ2 = 5.482 4, P <0.05). ③ There was no significant difference between the observation group and the control group in the incidence of adverse drug reactions within 15 days of treatment (14.00% (7/50) vs 18.00% (9/50)] (χ2 = 0.297 6, P> 0.05 ). Conclusion: Phentolamine and magnesium sulfate combined treatment of PIH can significantly improve the therapeutic effect without increasing the incidence of adverse drug reactions.