论文部分内容阅读
目的:观察苯磺酸氨氯地平与依那普利联合应用治疗中老年原发性高血压的降压疗效及对肾的保护作用。方法:选取中老高血压患者96例,随机分为2组。对照组予以依那普利5mg.d-1口服,实验组给予苯磺酸氨氯地平5mg.d-1口服+依那普利5mg.d-1口服,比较2组治疗前和治疗8周后血压及肾功能的变化。结果:2组治疗前后的收缩压、舒张压均有显著变化(P<0.05);2组治疗后比较,差异也存在显著性(P<0.05);两药联合治疗的实验组治疗后肾功水平较前好转,差异有显著性(P<0.05)。结论:钙离子拮抗剂(CCB)苯磺酸氨氯地平与血管紧张素转化酶抑制剂(ACEI)依那普利联合应用可显著降血压并对肾有保护作用。
Objective: To observe the antihypertensive efficacy of amlodipine besylate combined with enalapril in the treatment of middle-aged and elderly patients with hypertension and its protective effect on the kidney. Methods: 96 middle-aged and elderly hypertensive patients were selected and randomly divided into two groups. The control group was enalapril 5mg.d-1 orally, the experimental group was given amlodipine besylate 5mg.d-1 orally + enalapril 5mg.d-1 orally, compared two groups before treatment and 8 weeks of treatment After blood pressure and renal function changes. Results: Before and after treatment, the systolic and diastolic blood pressures were significantly changed (P <0.05). There was also significant difference between the two groups after treatment (P <0.05). After treatment, the renal function The level was better than before, the difference was significant (P <0.05). CONCLUSION: Combined use of calcium ion antagonist (CCB) amlodipine besylate and ACE inhibitor enalapril can significantly lower blood pressure and protect kidney.