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为探讨室房传导(VAC)所致的起搏器综合征(PMS),于植入起搏器术中观察室房顺序起搏(VAP)引起的血液动力学及神经体液因子的变化。19例患者中,VAP使26.3%的患者出现典型的PMS。VVI起搏仅使15.8%的患者出现轻度症状。VAP及VVI起搏均引起血浆心钠素及去甲肾上腺素增高(P均<0.01),后者增高的程度VAP(73.1±53.2pg/ml)大于VVI起搏(35.6±46.3pg/ml),P<0.05。研究结果表明VAC是PMS最重要的致病因素。
To investigate the pacemaker syndrome (PMS) caused by ventricular conduction (VAC), we observed the changes of hemodynamics and neurohumoral factors induced by ventricular sequential pacing (VAP) during the implantation of pacemaker. Among 19 patients, VAP caused typical PMS in 26.3% of patients. VVI pacing only mild symptoms of 15.8% of patients. Both VAP and VVI pacing resulted in an increase in plasma atrial natriuretic peptide and norepinephrine (P <0.01), while the latter was higher in VAP (73.1 ± 53.2 pg / ml) than in VVI pacing (35%). 6 ± 46.3 pg / ml), P <0.05. The results show that VAC is the most important PMS risk factors.