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目的分析纳络酮治疗中重度新生儿缺血缺氧性脑病患者血浆白细胞介素6(IL-6)和C-反应蛋白(CRP)的变化,探讨纳络酮在新生儿急性缺血性脑血管病治疗中的相关机制。方法选择44例中重度HIE患儿,随机分为纳络酮治疗组和丹参治疗组。纳络酮治疗组:予纳络酮0.2mg加10%葡萄糖40ml 4 h滴完,1次/d,连续4 d。丹参治疗组:予复方丹参注射液2～4ml加入10%葡萄糖溶液20～30ml静脉滴注。1次/d,连续4 d。各组与治疗前后均用酶联免疫吸附法(ELISA)测定上述因子,比较它们的差异。结果纳络酮治疗组4d后,患儿NBNA评分明显改善,血浆IL-6和CRP比丹参治疗组明显降低。结论纳络酮治疗HIE与其抗炎症反应有关。
Objective To analyze the changes of plasma interleukin 6 (IL-6) and C-reactive protein (CRP) in patients with moderate-severe neonatal hypoxic-ischemic encephalopathy treated with naloxone and to investigate the effects of naloxone on acute ischemic brain Related mechanisms in the treatment of vascular disease. Methods Forty-four children with moderate-severe HIE were randomly divided into naloxone treatment group and Salvia miltiorrhiza treatment group. Naloxone treatment group: naloxone 0.2mg plus 10% glucose 40ml 4 hours drip finished, 1 times / d, for 4 days. Salvia treatment group: to compound Danshen injection 2 ~ 4ml added 10% glucose solution 20 ~ 30ml intravenous drip. 1 times / d, for 4 days. The above factors were determined by enzyme-linked immunosorbent assay (ELISA) in all groups and before and after treatment, and their differences were compared. Results After 4 days of naloxone treatment, the score of NBNA in children was significantly improved, and the levels of IL-6 and CRP in plasma were significantly lower than those in the Salvia miltiorrhiza group. Conclusion Naloxone treatment of HIE and its anti-inflammatory response.