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目的探讨代谢综合征与中青年急性脑梗死的关系。方法对确诊急性脑梗死年龄在35～60岁之间患者198例,根据代谢异常分为代谢综合征组和非代谢综合征组,分别对其进行临床和颈部血管超声分析。结果(1)合并代谢综合征者112例,占全部病例56.5%。代谢综合征组吸烟饮酒者比例高,脑梗死的复发率37.1%,而非代谢综合征组仅17.6%。(2)代谢综合征组代谢紊乱主要表现为:肥胖(BMI28.62±4.06Kg/m2),血压高尤以收缩压升高明显(159.62±20.04mmHg),高空腹血糖(145.02±76.33mg/dl)、高甘油三酯血症(234.54±50.71mg/dl)及低高密度脂蛋白胆固醇血症(38.36±9.66)。(3)代谢综合征组纤维蛋白原升高明显,且动脉粥样硬化及斑块形成比例高。结论代谢综合征通过促使动脉粥样硬化及血栓形成,导致中青年急性脑血管意外的发生增加,在中青年急性脑梗死的发生中具有重要作用。
Objective To investigate the relationship between metabolic syndrome and acute cerebral infarction in middle-aged and young adults. Methods A total of 198 patients with acute cerebral infarction aged from 35 to 60 years old were divided into metabolic syndrome group and non-metabolic syndrome group according to the metabolic abnormalities, and their clinical and cervical vascular ultrasound were analyzed respectively. Results (1) 112 patients with metabolic syndrome, accounting for 56.5% of all cases. Metabolic syndrome smoking high proportion of drinkers, the recurrence rate of 37.1% of cerebral infarction, non-metabolic syndrome group only 17.6%. (2) Metabolic syndromes mainly manifested as metabolic disorder (BMI28.62 ± 4.06Kg / m2), high blood pressure, especially systolic blood pressure (159.62 ± 20.04mmHg), high fasting blood glucose (145.02 ± 76.33mg / dl), hypertriglyceridemia (234.54 ± 50.71 mg / dl) and low-density lipoprotein cholesterol (38.36 ± 9.66). (3) Metabolic syndrome increased significantly fibrinogen, and atherosclerosis and plaque formation of a high proportion. Conclusion Metabolic syndrome plays an important role in the pathogenesis of acute cerebral infarction in middle-aged and young adults by inducing atherosclerosis and thrombosis.