急性肺损伤与急性呼吸窘迫综合征是同一疾病的不同发展阶段,肺水肿是两者的主要病理改变之一。肺水肿与肺泡液体清除率之间存在密切关系,提高肺泡液体清除率可以加快肺泡水肿液体的吸收。大量研究表明,上皮钠通道和囊性纤维跨膜电导调节因子氯通道是参与肺泡水肿液体清除过程的重要通道,它们的缺失或功能障碍会导致肺泡水肿液体的清除受阻。本文就肺泡液体清除机制及上述两种通道在这一过程中所发挥的作用做一阐述。 Acute lung injury and acute respiratory distress syndrome are different stages of development of the same disease, pulmonary edema is one of the major pathological changes. There is a close relationship between pulmonary edema and alveolar fluid clearance. Increasing alveolar fluid clearance can speed up the absorption of alveolar edema fluid. Numerous studies have shown that epithelial sodium channel and cystic fibrosis transmembrane conductance regulator chloride channel is an important channel involved in the liquid clearance of alveolar edema, their loss or dysfunction can lead to the removal of alveolar edema fluid blocked. In this paper, the mechanism of alveolar fluid clearance and the role of the two channels in this process are described.