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母-胎界面是胚胎和母体直接接触的部位,母体和胚胎之间发生着复杂的对话,细胞、细胞因子及细胞外基质之间构成相互作用的复杂网路,形成了母-胎界面上特有的免疫耐受状态,以维持正常妊娠。T细胞抗原受体γδT细胞作为T细胞的一个特殊亚群,主要分布在黏膜和上皮组织,是机体的一种重要的免疫细胞,以非主要组织相容性复合体(MHC)限制性的方式识别各种抗原,在黏膜免疫中发挥重要作用。母-胎界面上的T细胞抗原受体(TCR)γδT细胞对母-胎免疫耐受状态的维持起重要作用,与正常妊娠及复发性自发性流产均有着密切的关系。
The maternal-fetal interface is where the embryo interacts directly with the maternal body. Complex interactions occur between the maternal and embryo, and complex networks of cells, cytokines and extracellular matrix that form an interaction between the maternal-fetal interface Immune tolerance to maintain normal pregnancy. As a special subpopulation of T cells, T cell antigen receptor γδT is mainly distributed in the mucosa and epithelium and is an important immune cell in the body. In a non-major histocompatibility complex (MHC) -restrictive manner Identify a variety of antigens, play an important role in mucosal immunity. T cell antigen receptor (TCR) γδT cells at the maternal-fetal interface play an important role in the maintenance of mother-fetar immune tolerance, and are closely related to normal pregnancy and recurrent spontaneous abortion.