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目的:优化杨梅素分散片的处方,并对其相关性能进行考察。方法:首先以片剂外观和崩解时间为指标,初步筛选片剂基本处方,然后采用L_9(3~4)正交试验设计法,以分散片的外观、体外溶出度及混悬性为指标,以综合评分法对处方进行优化,并采用紫外分光光度法分别对杨梅素分散片和普通片在不同时间内的溶出度进行了比较。结果:优化后的处方制得的分散片外观光洁。溶出度测定显示杨梅素分散片在15min和45min的溶出度分别达82.36%和93.14%,而杨梅素普通片在15 min的累积溶出度仅为67.68%。结论:本制备工艺简单可行;杨梅素分散片与普通片相比,分散片起始溶出快,可较快地发挥药效作用。
OBJECTIVE: To optimize the prescription of myricetin dispersible tablets and investigate its related performance. Methods: Firstly, the basic formulation of tablets was initially screened by the appearance and disintegration time of tablets. Then the design of L9 (3-4) orthogonal design was used to evaluate the appearance, in vitro dissolution and suspension of the tablets , The prescription was optimized by the comprehensive score method, and the dissolution of myricetin dispersible tablets and ordinary tablets in different time were compared respectively by UV spectrophotometry. Results: The dispersible tablets prepared by the optimized prescription have a smooth appearance. The dissolution of myricetin dispersible tablets showed 82.36% and 93.14% dissolution rates at 15min and 45min, respectively. The dissolution rate of myricetin tablets at 15min was only 67.68%. Conclusion: The preparation process is simple and feasible; myricetin dispersible tablets compared with ordinary tablets, dispersible tablets start dissolving fast, can play a faster effect.