本文对经B型超声确诊的25岁以上的176名女性胆囊结石病人进行配对病例对照研究.多因素条件Logistic回归分析结果提示:高血浆孕酮水平是女性胆囊结石发生的危险因素.月经初潮年龄、流产次数、口服避孕药及肥胖与女性胆囊结石的发生有关.交互作用分析发现:育龄妇女血浆孕酮与雌二醇、体重指数与口服避孕药之间在女性胆囊结石的发生中起协同作用. In this paper, 176 cases of female cholecystolithiasis over the age of 25 diagnosed by type B ultrasound were compared.Multivariate Logistic regression analysis showed that high plasma progesterone level is a risk factor for the occurrence of gallstone in women.The age of menarche , The number of miscarriage, oral contraceptives and obesity were related to the occurrence of gallstone in females.It was found by interaction analysis that the synergistic effect of progesterone and estradiol in women of childbearing age, the body mass index and oral contraceptives occurred in the occurrence of gallstone in women .