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目的:了解菊花和大黄中有害元素Cu,Pb,Cd,Hg,As的存在状态及其分布。方法:采用改良的Tessier连续提取法制备样品;用原子吸收光谱法测定Cu,Pb,Cd的含量,原子荧光光度法测定Hg,As的含量。结果:菊花中Cu,Pb,Cd,Hg,As的含量分别为12.806,10.478,0.436,0.231,1.531 mg.kg-1。Cu,Pb,Hg以残渣态和有机结合态为主;Cd以离子交换态为主;As以残渣态为主,离子交换态与水溶态也占有较大比例。大黄中Cu,Pb,Cd,Hg,As的含量分别为10.530,4.926,0.478,0.260,0.750 mg.kg-1。Cu,Pb,Hg以残渣态比例最高,Cd和As以离子交换态为主。结论:连续提取法用于中药有害元素形态分析,总体上能反映药材中有害元素的存在形式与分布情况,能较全面地提供有害元素的信息,对中成药与中药提取物生产、中药材生产、加工与炮制、中药新药研发和安全性评价等具重要的参考价值。
Objective: To understand the existing state and distribution of harmful elements Cu, Pb, Cd, Hg, As in chrysanthemum and rhubarb. Methods: Samples were prepared by a modified Tessier continuous extraction method. The contents of Cu, Pb and Cd were determined by atomic absorption spectrometry. The contents of Hg and As were determined by atomic fluorescence spectrometry. Results: The contents of Cu, Pb, Cd, Hg and As in chrysanthemum were 12.806,10.478,0.436,0.231,1.531 mg.kg-1 respectively. Cu, Pb and Hg are mainly in the form of residues and organic bounds; while Cd is mainly ion-exchangeable; while As is mainly in the form of residuals, and ion-exchange and water-soluble forms also occupy a large proportion. The contents of Cu, Pb, Cd, Hg and As in rhubarb were 10.530, 4.926, 0.478, 0.260 and 0.750 mg.kg-1, respectively. The contents of Cu, Pb and Hg were the highest in the residual state, and the contents of Cd and As were mainly in the ion exchange state. Conclusion: The continuous extraction method is used for the morphological analysis of harmful elements in traditional Chinese medicine, which can reflect the existing forms and distribution of harmful elements in the whole medicine. It can provide the information of harmful elements more comprehensively. , Processing and processing, research and development of new Chinese medicine and safety evaluation of an important reference value.