吗啡是目前临床用于治疗严重癌性疼痛的最有效药物,但除了作用于中枢神经系统减轻疼痛外,还会导致成瘾性、呼吸抑制和便秘等副作用。近年来吗啡与肿瘤生长的相关性日益受到重视,越来越多的研究表明吗啡与肿瘤的细胞增殖、迁移与侵袭、血管形成及凋亡等相关;同时吗啡还可调控免疫系统,通过对NK细胞的活性、T细胞的增殖活化、IL-2及TNF表达的影响,间接影响肿瘤的生长。 Morphine is currently the most clinically useful drug for the treatment of severe cancerous pain, but in addition to acting on the central nervous system to relieve pain, it can also cause side effects such as addiction, respiratory depression and constipation. In recent years, the relationship between morphine and tumor growth has been paid more and more attention. More and more researches show that morphine is related to tumor cell proliferation, migration and invasion, angiogenesis and apoptosis. At the same time, morphine can regulate the immune system, Cell activity, T cell proliferation and activation, IL-2 and TNF expression, indirectly affect tumor growth.