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目的:探讨输卵管切除术对体外受精-胚胎移植(IVF-ET)治疗患者卵巢功能的影响。方法:选择在本中心行输卵管切除,且手术前、后均IVF-ET治疗的46例患者,共92个治疗周期。其中单侧输卵管切除22例,双侧输卵管切除24例。记录卵巢超促排卵过程中的各项指标,比较输卵管切除前、后卵巢对超促排卵治疗的反应。结果:单侧输卵管切除患者:切除前、后的促性腺激素(Gn)用药天数、Gn用量、E2值(hCG日血清E2值)、获卵数、有效胚胎数、优质胚胎数均无显著性差异(P>0.05)。与切除前比,双侧输卵切除患者切除后Gn用药天数较长(P<0.05),Gn用量较大(P<0.05);切除前、后的E2值、获卵数、有效胚数、优质胚胎数均无显著性差异(P>0.05)。结论:单侧输卵管切除术不影响卵巢对超促排卵治疗的反应性。双侧输卵管切除术将降低卵巢对Gn的敏感性,使Gn的用药天数和用药量增加,切除双侧输卵管需谨慎。
Objective: To investigate the effect of tubal resection on ovarian function in patients undergoing in vitro fertilization-embryo transfer (IVF-ET). Methods: Forty-six patients treated with IVF-ET before surgery and after surgery underwent tubal resection in our center for a total of 92 cycles. Including unilateral tubal resection in 22 cases, bilateral tubal resection in 24 cases. Record the indicators of ovarian hyperstimulation in the process of tubal excision before and after ovarian response to the treatment of super-ovulation. Results: Unilateral tubal resection patients had no significant difference in Gn administration time, Gn dosage, E2 value (hCG day serum E2 value), number of oocytes retrieved, number of effective embryos and number of high quality embryos Difference (P> 0.05). Compared with those before resection, Gn administration was longer (P <0.05) and Gn was more significant (P <0.05) after excision of the patients with bilateral oophorectomy; E2 value before and after resection, number of oocytes retrieved, number of effective embryos, No significant difference in the number of high-quality embryos (P> 0.05). Conclusion: Unilateral tubal excision does not affect ovarian response to hyperstimulation. Bilateral salpingo-oophorectomy will reduce ovarian Gn sensitivity, so Gn medication days and the amount of medication increased, removal of bilateral fallopian tubes need to be cautious.