目的探讨中老年部分睾酮缺乏综合征(PADAM)与中老年抑郁症的关系。方法对PADAM量表测评为PADAM的病人另给予抑郁自测量表(SDS)测评,SDS评分增高者分成治疗与对照二组,治疗组给予十一酸睾酮(安特尔)胶囊口服。每2周门诊随访一次,观测抑郁症状的变化及服用后有无副作用。3个月后,予两个表复测评估。结果除PADAM症状明显缓解外,抑郁症状明显改善,全部SDS的评分均明显下降,与服用雄激素之前有明显差异。结论中老年抑郁症与PADAM明显相关,服用雄激素补充后抑郁症状明显改善。 Objective To investigate the relationship between partial testosterone deficiency syndrome (PADAM) and depression in middle-aged and senile patients. Methods Patients with PADAM scale were assessed by PADAM. Self-rating depression scale (SDS) was also used to evaluate the effect of SDS. The patients with higher SDS score were divided into treatment and control groups. The treatment group was orally administered with testosterone undecanoate. Follow up every 2 weeks to observe the changes of depression symptoms and whether there are any side effects after taking it. Three months later, two tables were retested. Results In addition to the obvious alleviation of symptoms of PADAM, depression symptoms were significantly improved, all SDS scores were significantly decreased, and before taking androgen were significantly different. Conclusions Depression in middle-aged and elderly patients is significantly associated with PADAM. Depression symptoms after androgen supplementation were significantly improved.