据估计,临床使用的药物中60%利用细胞色素P450(CYP)3A途径进行生物转化。因此,采用同一途径代谢的药物同时服用时,药代动力学方面的可能的药物相互作用有着明确的临床相关性。使用咪达唑仑(midazolam)作为CYP3A底物原型,CYP3A抑制剂分类系统把使咪达唑仑血浆曲线下面积增加≥5 It is estimated that 60% of clinically used drugs utilize the cytochrome P450 (CYP) 3A pathway for bioconversion. Thus, the potential for drug-pharmacokinetic drug interactions to be clearly clinically relevant with concurrent use of drugs metabolized by the same pathway. Using midazolam as a prototype of CYP3A substrate, the CYP3A inhibitor classification system increased the area under the midazolam plasma curve by ≧ 5