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目的观察更昔洛韦联合丙种球蛋白治疗先天性巨细胞病毒(CMV)感染的疗效。方法将54例CMV感染患儿随机分成2组,每组27例。治疗组在常规治疗基础上加用更昔洛韦5mg/kg静脉滴注,2次/d,连用14d,维持量5mg/kg,1次/d,连用14d。丙种球蛋白400mg/kg,1次/d,连用3d。对照组予常规治疗。结果治疗组和对照组在疗程结束后,在临床表现、实验室检查及病毒学结果转归方面进行比较,差异有统计学意义(P<0.05)。结论更昔洛韦联合丙种球蛋白治疗先天性巨细胞病毒感染疗效较好,且不良反应小,值得临床推广。
Objective To observe the curative effect of ganciclovir combined with gamma globulin in the treatment of congenital cytomegalovirus (CMV) infection. Methods 54 cases of CMV infection were randomly divided into two groups, 27 cases in each group. The treatment group was given intravenous infusion of ganciclovir 5mg / kg on the basis of routine treatment for 14 days, and the maintenance dose was 5mg / kg, once daily for 14 days. Gamma globulin 400mg / kg, 1 / d, once every 3d. Control group to conventional treatment. Results After treatment, the treatment group and the control group were compared in terms of clinical manifestations, laboratory tests and outcome of virological outcomes (P <0.05). Conclusion Ganciclovir combined with gamma globulin in the treatment of congenital cytomegalovirus infection is better, and the adverse reactions are small, worthy of clinical promotion.