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目的:观察注射用唑来膦酸治疗恶性肿瘤骨转移性疼痛的效果和不良反应。方法:67例恶性肿瘤骨转移性疼痛的患者,每次给予唑来膦酸注射液4mg,用生理盐水100ml稀释后静脉滴注,每3-4周1次,至少连续2次。结果:止痛效果:显效23.9%(16/67),有效46.2%(31/67),总有效率70.1%,活动能力总改善率64.2%(43/67),生活质量改善总有效率65.6%(44/67)。主要不良反应为发热、一过性肌肉骨关节痛、流感样症状等,反应轻,不需特殊处理。结论:唑来膦酸注射液能明显减轻恶性肿瘤骨转移性疼痛和显著提高患者的生活质量。
Objective: To observe the effects and adverse reactions of zoledronic acid for the treatment of metastatic bone pain in malignant tumors. METHODS: Sixty-seven patients with metastatic bone metastatic pain were given zoledronic acid injection 4 mg each time, diluted with saline 100 ml, intravenously once every 3-4 weeks, at least 2 consecutive times. Results: Analgesic effect: markedly effective 23.9% (16/67), effective 46.2% (31/67), total effective rate 70.1%, total activity improvement rate 64.2% (43/67), improvement of total quality of life efficiency 65.6% (44/67). The main adverse reactions were fever, transient muscle and joint pain, and flu-like symptoms. The response was mild and no special treatment was required. Conclusion: Zoledronic acid injection can significantly reduce bone metastatic pain in malignant tumors and significantly improve the patient’s quality of life.