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本文用Каверина法在猫及兔上进行冠状窦插管,直接記录冠脉血流量,并同时抽取动脉及冠状窦血液,测定氧、糖、乳酸及丙酮酸含量之差,計算心肌对它們的消耗量。部分实驗在稳压装置情况下进行。 靜脉注射抗坏血酸0.2克/公斤,冠脉血流量在兔上平均墳加76％,猫平均增加24％,心肌氧耗量无明显改变,注入抗坏血酸0.4克/公斤,冠脉血流量兔平均增加125％,猫平均增加95％,稳压情况下,猫平均增加62％,心肌氧耗量傾向降低,而糖、乳酸及丙酮酸的心肌消耗量无明显改变。抗坏血酸增加冠脉血流量的作用,并非完全取决于血压,亦不是由于血中乳酸含量增加,而是有直接扩張冠状血管的作用。 靜脉注射抗坏血酸呈現的心脏功能改善与增加冠脉血流量、經济心肌耗氧和不明显地影响心肌糖代謝有关。
In this paper, Каверина method for coronary sinus intubation in cats and rabbits, direct recording of coronary blood flow, and simultaneous extraction of arterial and coronary sinus blood, determination of oxygen, sugar, lactic acid and pyruvate difference between the calculation of myocardial on them consumption. Some experiments in the case of voltage regulator. Intravenous injection of ascorbic acid 0.2g / kg, coronary blood flow average graves plus 76% in rabbits, cats an average increase of 24%, no significant changes in myocardial oxygen consumption, injection of ascorbic acid 0.4g / kg, coronary blood flow increased by an average of 125 rabbits %, While cats increased 95% on average. Cats increased 62% on average on steady-state pressure, and their myocardial oxygen consumption tended to decrease. However, the myocardial consumption of sugar, lactate and pyruvate did not change significantly. Ascorbic acid to increase the role of coronary blood flow, not entirely dependent on blood pressure, nor is it due to increased blood levels of lactic acid, but a direct expansion of coronary blood vessels. Intravenous ascorbate presents an improvement in cardiac function associated with increased coronary blood flow, economic myocardial oxygen consumption, and an insignificant effect on myocardial glucose metabolism.