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乙型肝炎病毒(HBV)是一种类反转录(retroid)病毒,其DNA基因组短小,编码能力有限;但HBV却能成功地在不同宿主个体中繁殖,并在人群中广泛传播。本文着重对HBV与宿主细胞关系的研究进展进行综述,以利于阐明HBV复制及其在宿主细胞内持续存在的特性。这些内容主要来自于本实验室的研究。文中讨论的HBV与宿主之间的相互作用主要包括:细胞伴侣分子在HBV反转录起始和核衣壳组装中的作用,宿主通过调控核衣壳磷酸化对病毒衣壳成熟的调节以及与HBV持续存在相关的核内附加体(episomal)病毒DNA的形成。
Hepatitis B virus (HBV) is a type of retroid virus with a short DNA genome and limited coding capacity. However, HBV can successfully propagate in different host individuals and spread widely in the human population. This article focuses on the research progress of the relationship between HBV and host cells in order to clarify the characteristics of HBV replication and its persistence in host cells. These mainly come from the research of this laboratory. The interactions between HBV and host discussed in this paper mainly include the roles of cellular chaperones in initiation of HBV reverse transcription and assembly of nucleocapsid, host regulation of viral capsid maturation through regulation of nucleocapsid phosphorylation, The persistence of HBV is associated with the formation of episomal viral DNA in the nucleus.