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本文研究了至今尚不完全清楚的胆碱酯酶抑制剂梭曼引起肌麻痹的机理。建立了大鼠高体不均匀牵拉的膈肌标本。排除了文献上用箭毒或高镁离子制动的干扰和切压肌肉制动引起的创伤。该标本膜电位正常、终板电位(EPP)高达30-36mV,还可同时记录到频率和幅度正常的小终板电位(MEPP)。此标本用来研究药物对接头的作用优于其他标本。 当给予5.5μM梭曼后,串刺激(50Hz,1.0s)膈神经时,第一个EPP幅度加大,半降期延长。第10个及
In this paper, we have not yet fully understood the cholinesterase inhibitor soman caused by muscle paralysis mechanism. Diaphragm specimens with unevenly drawn rat body were established. Ruled out the literature with the arrowhead or high magnesium ions brake interference and cut the muscle injury caused by braking. The specimen membrane potential is normal, the endplate potential (EPP) up to 30-36mV, but also to the frequency and amplitude of normal small endplate potential (MEPP). This specimen was used to study the effect of drugs on the adapter better than other specimens. When 5.5 μM soman was stimulated by the skeletal stimulation (50 Hz, 1.0 s) of the phrenic nerve, the amplitude of the first EPP was increased and the half-fall was prolonged. The 10th and